Pair Name	Dihydroartemisinin, Osimertinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Down-regulation	Expression	HMOX1	hsa3162
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_B260
	PC-9/GR4	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_DH34
In Vivo Model	PC-9 or PC9-GR4-AZD1 cells (4×10⁶ cells resuspended in 200 μl of 1:1 mixture of PBS / Corning Matrigel Basement Membrane Matrix) were injected subcutaneously into the right flank of mice.
Result	The results suggest that DHA is able to reverse the resistance to osimertinib in EGFR-mutant NSCLC by elevating ROS level and impair heme metabolism.